Trials / Completed
CompletedNCT03193177
A Retrospective and Prospective Cohort Study of the 21-day Fasting-like Diet in Patients With Metabolic and Autoimmune Diseases
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 144 (actual)
- Sponsor
- Tsinghua University · Academic / Other
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
Effectiveness of fasting or fasting-mimicking diet has been proved an effective approach to treat metabolic and autoimmune diseases in mice. However, clinical trials performing prolonged fasting with more than 7 days have not been reported. Investigators conduct an open label, phase I/II clinical trial to evaluate the safety and effectiveness of the 21-day fasting-like diet in the treatment of metabolic and autoimmune diseases.
Detailed description
Although fasting has been proved an effective approach to treat metabolic and autoimmune diseases in mice, prolonged fasting is difficult to implement in human-beings for the safety and feasibility reasons. In this clinical trial, we will recruit metabolic and autoimmune diseases and then follow a traditional Chinese 21-day fasting-like diet process with extremely low calorie intake (about 5% of normal diet) and prolonged fasting-like period. Blood, urine, stool samples will be collected on day 0 (baseline), day 4, day 7, day 14, day 21 and day 51 after it started up. Therefore we can examine the changes of disease-associated physical indexes and metabolic biomarkers pre and post the 21-day fasting-like diet. The purpose of the study is to ascertain the impact of the fasting-like diet during the 21 days. The investigators hypothesize that the 21-day fasting-like diet can reduce the biomarkers associated with aging and age-related diseases and benefit for the treatment of metabolic and autoimmune diseases.
Conditions
- Fasting
- Chronic Disease
- Autoimmune Diseases
- Metabolic Disease
- High Blood Pressure
- Fatty Liver
- Kidney Stone
- Gall Stone
- Hysteromyoma
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | the 21-day fasting-like diet | a fasting-like diet with 400 KJ energy intake per day for 21 days |
Timeline
- Start date
- 2017-06-20
- Primary completion
- 2018-08-31
- Completion
- 2018-12-31
- First posted
- 2017-06-20
- Last updated
- 2019-09-06
Locations
1 site across 1 country: China
Source: ClinicalTrials.gov record NCT03193177. Inclusion in this directory is not an endorsement.