NCT03189628

The Effect of Autologous Stromal Vascular Fractions on Skin Regeneration

Study of Autologous Stromal Vascular Fraction From Adipose Tissue in Promoting Skin Regeneration

• Status: Unknown
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Shanghai Jiao Tong University School of Medicine · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to observe whether the transplantation of autologous stromal vascular fraction (SVF) in adipose tissue is safe and its effect on improving skin regeneration.

Detailed description

This is a randomized controlled single blind clinal trial that designed to observe whether the transplantation of autologous stromal vascular fraction (SVF) in adipose tissue is safe and its effect on improving skin regeneration. The clinical trial will concentrate on the therapeutic effect of SVF after facial injection. After 1, 4, 8, 12, 24 and 48 weeks of treatment, a comprehensive examination of the facial skin was performed to assess the effect of the SVF. Skin texture, thickness and colour will be observed to evaluate the effect of SVF on skin regeneration

Conditions

• Skin
• Aging

Interventions

Type	Name	Description
BIOLOGICAL	stromal vascular fraction	The adipose tissue(no less than 40ml) in abdomen will be harvested and digested at 37 °C for (45-60) min with (0.125-1.5)mg/ml collagenase . After filtration and centrifugation at the speed of (700-1500)g, mature adipocytes are separated from the cell pellet. The pellet then is treated with saline twice to remove cell fragment and rudimental collagenase . The harvested pellet is stromal vascular fraction (SVF) The SVF was resuspended in 1 ml saline and transplanted for 3 area including the forehead、palpebra inferior and crow's-feet.
DRUG	Saline	1 ml saline was injected for 3 area including the forehead、palpebra inferior and crow's-feet.

Timeline

• Start date: 2017-03-13
• Primary completion: 2017-08-25
• Completion: 2018-03-13
• First posted: 2017-06-16
• Last updated: 2017-06-16

Locations

1 site across 1 country: China