NCT03189511

Effect of Fluvastatin on Brown Fat Activity

Short Term Effect of Fluvastatin on Brown Adipose Tissue Thermogenesis and Activity in Humans

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 17 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: Male
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to elucidate the effects of Fluvastatin on brown adipose tissue activity in humans.

Detailed description

Statins, inhibitors of cholesterol biosynthesis, act by inhibiting the enzyme of the mevalonate pathway. Although the clinical benefits of statins are undisputable, they have been shown to increase insulin resistance and incidence of type 2 diabetes mellitus, the mechanism of which is currently not clear. The main function of brown adipose tissue (BAT) is non-shivering thermogenesis (i.e. heat production through energy dissipation) in brown adipocytes. There has been a growing interest in BAT as a novel therapeutic approach to increase energy expenditure in order to facilitate weight-loss and increase insulin sensitivity. BAT activity will be assessed using calorimetric test and \[18F\]-Fluorodeoxyglucose (FDG) positron emission tomography (PET). We speculate that statins inhibit BAT function and that this mechanism may contribute to the above mentioned increase in insulin resistance.

Conditions

• Adipose Tissue, Brown
• Insulin Resistance
• Clinical Trial

Interventions

Type	Name	Description
DRUG	Fluvastatin	Fluvastatin 40 mg twice daily per mouth for 14 days.

Timeline

• Start date: 2017-05-31
• Primary completion: 2018-01-23
• Completion: 2018-02-19
• First posted: 2017-06-16
• Last updated: 2018-05-31

Locations

2 sites across 1 country: Switzerland