NCT03187366

Schistosomiasis in Senegal

EID: Using Community Ecology Theory to Predict the Effects of Agricultural Expansion and Intensification on Infections of Humans: Implications for Sustainable Agriculture

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 1,477 (actual)
• Sponsor: University of Notre Dame · Academic / Other
• Sex: All
• Age: 5 Years – 17 Years
• Healthy volunteers: Accepted

Summary

Schistosomiasis is a flatworm transmitted from freshwater snails to humans in the tropics. In addition to this infectious disease, tropical developing countries are faced with malnutrition. We propose to alter pesticide and compost use to reduce schistosomiasis and maintain or even improve crop production.

Detailed description

We propose two types of manipulations. Bottom-up manipulations will affect snail resources, whereas top-down manipulations will affect snail predators. For the bottom-up manipulations, we will clear schistosoma infections in school children, then remove the primary habitat for snails, the submerged macrophyte Ceratophyllum demersum (with proper unmanipulated controls), compost it, apply it to crops, and then quantify reinfection rates and crop yields. The second bottom-up manipulation will be to clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk herbicides, or eliminate herbicides and fertilizers), and then quantify reinfection rates and crop yields. Farmers will be compensated for any loss in yields. For the top-down manipulations, every village will receive prawns that depredate snails. We will clear schistosoma infections in school children, apply three agrochemical treatments (status quo control, shift to lower risk insecticides that don't kill prawns, or eliminate insecticides), and then quantify reinfection rates and crop yields. Farmers will be compensated for any loss in yields.

Conditions

• Schistosomiasis

Interventions

Type	Name	Description
OTHER	Bottom-up intervention	Some interventions are bottom-up, where we manipulate the resources of snails and some are top-down, where we manipulate the predators of snails.

Timeline

• Start date: 2017-01-02
• Primary completion: 2025-09-01
• Completion: 2025-09-01
• First posted: 2017-06-14
• Last updated: 2023-03-22

Locations

1 site across 1 country: Senegal