NCT03186053

Sodium Creatine Phosphate in Heart Valve Surgery

Cardioprotective Effects of Sodium Creatine Phosphate in Valve Surgery: A Prospective Randomized Controlled Study

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 250 (estimated)
• Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

To explore the effect of intraoperative sodium creatine phosphate on myocardial protection in patients undergoing valve surgery

Detailed description

Objective: To explore the effect of intraoperative sodium creatine phosphate on myocardial protection in patients undergoing valve surgery Methods: 250 patients undergoing valve surgery were randomly divided into experimental group and control group. 5g creatine phosphate was dissolved in 50ml saline solution. After induction of anesthesia, the patients were first given a load dose of 1g, 20min (30ml / h) , And then pumped at a rate of 1 g / h (10 ml / h). The control group was treated with saline in the same manner. The cTnI level was measured at the corresponding time points. Hemodynamic indexes and postoperative complications were recorded.

Conditions

• Heart Valve Diseases

Interventions

Type	Name	Description
DRUG	sodium creatine phosphate	sodium creatine phosphate .Loading dose followed by continuous infusion in operation
DRUG	saline	.Loading dose followed by continuous infusion in operation

Timeline

• Start date: 2017-06-15
• Primary completion: 2018-07-01
• Completion: 2018-12-31
• First posted: 2017-06-14
• Last updated: 2018-01-31

Locations

2 sites across 1 country: China