NCT03185104

Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers

Randomized Double-blind Placebo-controlled Trial of Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 196 (actual)
• Sponsor: The University of Hong Kong · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study measures and compares the effect of silver diamine fluoride (SDF) on caries increment in removable partial denture wearers. Half of the participants will SDF and while the other half will receive placebo.

Detailed description

Removable partial dentures are commonly constructed to replace missing teeth. It is observed that removable partial denture wearers are susceptible to dental caries. The mode of action of silver diamine fluoride on caries prevention is dual: fluoride ions interact synergistically with silver to react with hydroxyapatite to form fluorapatite, and silver is bactericidal by reacting with the thiol groups of the amino and nucleic acids that halt the metabolic and reproductive functions of the cariogenic bacteria.

Conditions

• Dental Caries
• Dental Caries of Root Surface

Interventions

Type	Name	Description
DRUG	Silver Diamine Fluoride	Silver diamine fluoride solution is applied to the dried and exposed coronal and root surfaces of all teeth by means of a disposable microbrush.
DRUG	Distilled Water	Distilled water is applied to the dried and exposed coronal and root surfaces of all teeth by means of a disposable microbrush.

Timeline

• Start date: 2013-11-01
• Primary completion: 2017-06-30
• Completion: 2017-12-31
• First posted: 2017-06-14
• Last updated: 2017-06-14