NCT03176836

Li-Fraumeni Syndrome Imaging Study

Novel Approaches to Molecular and Clinical Surveillance in Li-Fraumeni Syndrome - Pilot Study.

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: The Hospital for Sick Children · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Li-Fraumeni Syndrome (LFS) is a cancer predisposition disorder in which most affected individuals develop cancer during their lifetime. The majority of LFS patients carry a mutation in a gene called TP53, whose normal function is to control cell growth and prevent cells with damaged DNA from becoming cancerous. There is currently no way to determine when, where or what type of tumour will develop. This project will use novel techniques utilizing magnetic resonance imaging (MRI) to determine how sensitive they are at detecting very small tumors and how specific they are in terms of distinguishing malignant tumors from benign tumors.

Conditions

• Li-Fraumeni Syndrome

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Whole body STIR MRI	Standard technique that detects abnormalities related to excess of water in tissues (edema).
DIAGNOSTIC_TEST	DW-MRI	MRI technique that analyzes areas of dead cells within tissues, present in some types of tumor.
DIAGNOSTIC_TEST	PET-MRI	MRI technique that detect's the cells' use of glucose, more intensely in harmful cells.

Timeline

• Start date: 2016-06-20
• Primary completion: 2025-07-01
• Completion: 2025-12-31
• First posted: 2017-06-06
• Last updated: 2024-12-13

Locations

1 site across 1 country: Canada