NCT03167333

The Role of Synovitis in Osteoarthritis

Does Synovitis Affect Treatment Efficacy in Intra-articular Injection Therapy to Osteoarthritis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Taipei Veterans General Hospital, Taiwan · Other Government
• Sex: All
• Age: 45 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

To determine whether platelet-rich-plasma (PRP) or HA (hyaluronic acid)injection into synovitis in osteoarthritis(OA) knee can achieve improvement in knee function and reduce synovitis.

Detailed description

Methods: sixty patients with OA knee having unilateral or bilateral synovitis validated by ultrasound (N=40) were studied. All the patients were randomized to receive PRP (N=40) or Hyaluronic acid(HA)(N=40) injection twice at 2-week intervals; Clinical assessments were performed using a visual analog scale(VAS) and The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC index) before injection at baseline, 4 weeks(first evaluation) and 12 weeks(secondary evaluation). Imaging evaluation based on color Doppler ultrasound(CDUS) and the depth of synovial fluid accumulation ,and the width of synovial hypertrophy was performed simultaneously.

Conditions

• Synovitis of Knee
• Osteoarthritis, Knee

Interventions

Type	Name	Description
DRUG	platelet rich plasma	The amount of PPR was about 4-5 cc
DRUG	Hyaluronic acid	HA was 2.5cc

Timeline

• Start date: 2020-03-01
• Primary completion: 2020-03-01
• Completion: 2020-03-01
• First posted: 2017-05-25
• Last updated: 2020-02-11

Locations

1 site across 1 country: Taiwan