NCT03164941

Effect of SLT Location on Treatment Outcomes

Effect of 180 Degree Selective Laser Trabeculoplasty Location on Treatment Outcomes

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 84 (estimated)
• Sponsor: St. Joseph's Healthcare Hamilton · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Selective Laser Trabeculoplasty (SLT) is a glaucoma treatment that has been shown to effectively lower intraocular pressure by increasing aqueous outflow through macrophage recruitment. There is evidence of increased drainage in the nasal quadrants of the eye. This study aims to compare whether there is a difference in the reduction of eye pressure when SLT is performed nasally and temporally.

Detailed description

This study aims to evaluate if there is a difference between 180 degree nasal and temporal selective laser trabeculoplasty (SLT) in treatment outcomes. It is known that there is increased aqueous collectors and veins and thus aqueous drainage in the nasal quadrants of the eye. If SLT works by the hypothesized biologic mechanism in which macrophages remodel the aqueous drainage system to increase outflow, performing SLT in an area concentrated with aqueous veins may increase outflow more. As a result, we hypothesize that nasal 180 degree SLT may have better outcomes compared to the temporal counterpart. The results of this study may help inform decisions when performing 180 degree SLT and provide insight to SLT's mechanism of action. The primary objective of this study is to determine if there is a difference in treatment efficacy between nasal and temporal 180 degree SLT by measuring differences in baseline and post-operative intraocular pressures. We hypothesize that nasal SLT will have superior outcomes compared to temporal SLT due to increased number of aqueous veins.

Conditions

• Glaucoma

Interventions

Type	Name	Description
PROCEDURE	Selective Laser Trabeculoplasty	Laser treatment for glaucoma.

Timeline

• Start date: 2017-07-01
• Primary completion: 2019-12-01
• Completion: 2020-12-01
• First posted: 2017-05-24
• Last updated: 2017-05-24

Locations

1 site across 1 country: Canada