NCT03154814

Ulinastatin Improves Postoperative Oxygenation After Cardiopulmonary Bypass

High-dose Ulinastatin Improves Postoperative Oxygenation in Patients Undergoing Aortic Valve Surgery With Cardiopulmonary Bypass

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (actual)
• Sponsor: Konkuk University Medical Center · Academic / Other
• Sex: All
• Age: 19 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

Retrospective study determine whether ulinastatin enhances postoperative pulmonary oxygenation after cardiopulmonary bypass (CPB).

Detailed description

This retrospective study evaluate patients who underwent aortic valvular surgery under moderate hypothermic CPB. The patients were classified into two groups: patients in whom high-dose ulinastatin (10,000 U/kg and 5,000 U/kg/h) was administered during CPB (Group-U); and patients in whom ulinastatin was not administered (Group-C). We measured PaO2/FiO2 at the following time points: before CPB (Pre-CPB), 2 hours after weaning from CPB (Post-CPB) and within 6 hours after admission to the ICU. The lengths of ventilator care and ICU stay were also reviewed.

Conditions

• Cardiopulmonary Bypass
• Cardiac Surgery

Interventions

Type	Name	Description
DRUG	ulinastatin	ulinastatin (10000 U/kg and 5000 U/kg/h) was administered during CPB
DRUG	control	conventional CPB was applied without ulinastatin treatment

Timeline

• Start date: 2016-01-01
• Primary completion: 2017-04-01
• Completion: 2017-05-01
• First posted: 2017-05-16
• Last updated: 2017-05-16

Locations

2 sites across 1 country: South Korea