NCT03145350

The Effect of a High-fat vs. High-sugar Diet on Liver Fat Accumulation and Metabolism

The Effect of a High Fat Compared to a High Sugar Diet on Liver Fat Accumulation and Metabolism

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (actual)
• Sponsor: University of Oxford · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Accepted

Summary

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in the world. It is currently unclear why fat starts to accumulate in the liver, although both the amount and type of food consumed have been implicated. The majority of studies that have investigated the effects of dietary fat or sugar on liver fat have fed volunteers excess calories, which are known to increase liver fat. The effect of specific dietary components, when consumed as part of a diet not containing excess calories, on liver fat accumulation remains unclear.

Detailed description

This research aims to investigate the role excessive consumption of specific macronutrients may play in the development of NAFLD. This will be achieved by subjecting participants to two specific dietary interventions (high-fat, low-carbohydrate and low-fat, high-carbohydrate) in a randomized, crossover research design. Liver fat content, and whole-body and hepatic fasting and postprandial lipid metabolism will be assessed before and after the specific dietary interventions.

Conditions

• Fat; Liver
• NAFLD

Interventions

Type	Name	Description
OTHER	High-fat, low-carbohydrate	Dietary intervention: 4 week
OTHER	Low-fat, high-carbohydrate	Dietary intervention: 4 week

Timeline

• Start date: 2016-12-01
• Primary completion: 2019-12-01
• Completion: 2020-03-01
• First posted: 2017-05-09
• Last updated: 2020-03-27

Locations

1 site across 1 country: United Kingdom