NCT03138681

Rapid Antidepressant Effects of ATP and Phosphocreatine

A Preliminary Clinical Study on the Rapid Antidepressant Effects of Adenosine Triphosphate (ATP) and Phosphocreatine Combinated With Fluoxetine

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: Zhujiang Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This is a preliminary, double-blind clinical trail aimed to investigate whether the combination of fluoxetine with ATP or phosphocreatine has a rapid antidepressant effect. 42 patients with major depressive disorder (Hamilton Depression Rating Scale (HAMD) score \>= 20) will be recruited and divided into 3 groups randomly. This study involves two periods. In the first period, one group will be treated with fluoxetine and placebo, one with fluoxetine and ATP, and one with fluoxetine and phosphocreatine for 2 weeks. Placebo, ATP and phosphocreatine will be given intravenously, and fluoxetine orally. In the second period, each patient will be only given fluoxetine for 4 weeks.

Conditions

• Major Depressive Disorder

Interventions

Type	Name	Description
DRUG	Placebo	placebo is given intravenously twice a day for 14 days
DRUG	ATP	ATP (100mg) is given intravenously twice a day for 14 days
DRUG	Phosphocreatine	Phosphocreatine (1g) is given intravenously twice a day for 14 days

Timeline

• Start date: 2017-05-03
• Primary completion: 2019-04-30
• Completion: 2019-04-30
• First posted: 2017-05-03
• Last updated: 2017-05-08

Locations

1 site across 1 country: China