NCT03136081

Candida Host Defense Response After Septic Shock in the Critically Ill

IMMUNOCANDIDA Candida Host Defense Response After Septic Shock in the Critically Ill

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 50 (actual)
• Sponsor: University Hospital, Montpellier · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Septic shock is associated with acquired immunoparalysis which is associated with a high risk of nosocomial acquired infection. Nosocomial candidiasis is associated with a 50% rate of mortality but is difficult to diagnose. The use of colonization indexes and risk factors on the other hand expose to unnecessary use of antifungals. The aim of the present study is to evaluate whether the host response to infection associated with candida biomarkers would help to anticipate the candidiasis onset.

Detailed description

Single center prospective observationnal study. Inclusion: all consecutive patients subsequently to a septic shock with no Candida infection. Measured parameters: host response (HLADR, CD64, inflammatory cytokines consecutive to LPS exposition) and Candida biomarkers (beta D Glucan, Mannan Ag and Ig), demographics, outcome (occurence of Candida nosocomial infection, morbidity and survival)

Conditions

• Septic Shock
• Candidiasis

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Candidiasis infection occurence	Candidiasis infection occurence

Timeline

• Start date: 2014-06-01
• Primary completion: 2015-05-01
• Completion: 2015-05-01
• First posted: 2017-05-02
• Last updated: 2017-05-02

Locations

1 site across 1 country: France