NCT03130608

Inspiratory Muscle Training Post-Liver Transplant

Comparison of Inspiratory Muscle Training and Usual Care in Individuals Post-Liver Transplant

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 37 (actual)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Individuals with chronic liver disease develop significant muscle wasting that remains post-liver transplant. The transplant surgery additionally challenges respiratory mechanics. Respiratory muscle strength has been measured to be impaired in individuals post liver transplant. This study proposes an 8 week intervention designed to increase respiratory muscle strength and pulmonary function that we hypothesize will correlate to improved functional performance and quality of life post-liver transplant. Pre-test post-test design, that will randomize subjects into an experimental group that will receive the inspiratory muscle strengthening exercise in addition to usual post-liver transplant care and a control group that will only receive the usual post-transplant care. Up to 50 subjects will be recruited from the Post-Liver Transplant Outpatient Clinic at the Miami Transplant Institute. The subjects will have repeated measurements of respiratory muscle strength, pulmonary function, functional mobility performance, and quality of life at baseline, 4 weeks, and 8 weeks.

Conditions

• Liver Disease Chronic
• Muscle Weakness
• Respiratory Insufficiency

Interventions

Type	Name	Description
OTHER	Inspiratory Muscle Training	Subjects will breath through a hand held valve that has adjustable resistance to strengthen the muscles used for breathing. Subjects will perform the exercise approximately 20-30 minutes, twice a day for 8 weeks.

Timeline

• Start date: 2017-06-30
• Primary completion: 2021-05-31
• Completion: 2021-05-31
• First posted: 2017-04-26
• Last updated: 2021-06-21

Locations

1 site across 1 country: United States