NCT03130335

Intra-articular Autologous Bone Marrow Aspirate Injection for Knee Osteoarthritis

Intra-articular Autologous Bone Marrow Aspirate Injection for the Treatment of Knee Osteoarthritis: a Pilot Study With Radiological Follow-up

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Hospital for Special Surgery, New York · Academic / Other
• Sex: All
• Age: 18 Years – 79 Years
• Healthy volunteers: Not accepted

Summary

Knee osteoarthritis (OA) is a leading cause of disability. The objectives of treatment are to reduce pain, improve function, and slow down further breakdown of the knee. Recently, research on nonsurgical treatment options for knee OA has increased significantly. One potential treatment of interest is the use of stem cell injections. Stem cells are one's own cells that have the ability to divide into other types of cells, and may cause regrowth of cartilage when injected into the knee. There have been few, but promising, studies that show improvements in pain and function with stem cell injections in those with knee OA. Therefore, more research is needed to identify patients who might benefit from this injection. This pilot study will look at changes in pain and function for 20 patients at 1, 3, 6, and 12 months after a stem cell injection into the knee. Patients will also undergo magnetic resonance imaging at 6 months and 12 months following the injection.

Conditions

• Osteoarthritis, Knee

Interventions

Type	Name	Description
PROCEDURE	BMA Injection	Bone marrow will be aspirated from the iliac crest and injected into the knee.
BIOLOGICAL	BMA	Bone marrow will be aspirated from the iliac crest.

Timeline

• Start date: 2017-04-28
• Primary completion: 2019-08-12
• Completion: 2019-10-01
• First posted: 2017-04-26
• Last updated: 2020-01-14

Locations

1 site across 1 country: United States