NCT03126279

fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study

Predicting Chronic Post TKR Pain by Assessing Central Sensitisation Using Functional Brain MRI

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 50 (estimated)
• Sponsor: University of Nottingham · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Accepted

Summary

Painful osteoarthritis (OA) is the 4th largest cause of disability in the UK. Preoperative temporal summation, a measure of central pain facilitation, has been shown to predict postoperative pain after total knee replacement surgery (TKR). The assessment of the brain's response to noxious stimuli using non-invasive functional MRI (fMRI) may be key in identifying imaging biomarkers within the brain that map central sensitization changes seen in OA. fMRI may help explain why up to 20% of patients undergoing TKR surgery develop persistent post-operative pain. To test these concepts the study aims to functionally characterise the brain activity related to temporal summation of pain in healthy individuals and OA patients using a novel fMRI cuff algometer. Assessment of outcomes in terms of pain and function will be performed 6 months post TKR surgery

Conditions

• Osteoarthritis
• Pain
• Postoperative Pain
• Surgery

Interventions

Type	Name	Description
PROCEDURE	Total Knee Replacement Surgery	All chronic knee osteoarthritis patients will be recruited as they are on the NHS waiting list for a total knee replacement. Only this group will undergo the procedure

Timeline

• Start date: 2015-08-01
• Primary completion: 2017-06-01
• Completion: 2017-08-01
• First posted: 2017-04-24
• Last updated: 2017-04-24

Locations

1 site across 1 country: United Kingdom