Trials / Terminated
TerminatedNCT03121599
18F-FLT (PET/CT) in Pediatrics With Myeloproliferative Neoplasms
A Study of 18F-FLT Positron Emission Tomography (PET)/Computed Tomography Imaging in Pediatrics With Myeloproliferative Neoplasms
- Status
- Terminated
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 3 (actual)
- Sponsor
- Hamad Medical Corporation · Industry
- Sex
- All
- Age
- 14 Years – 18 Years
- Healthy volunteers
- Not accepted
Summary
The Main purpose of this project to study the uptake pattern of FLT-PET and it is value in assessing the malignant hematopoiesis in MPN within the pediatric age group, in terms of diagnosis, staging and monitoring response to therapy. As well as, evaluating FLT-PET as a novel non-invasive technique in cases with MPN and its role in comparison to the standard bone marrow biopsy with regard to disease diagnosis, assessment of disease activity, detection of transformation, monitoring of treatment response and grading of fibrosis.Furthermore, we aim to study the association of FLT-PET uptake patterns with different genetic makeup (JAK2, CALR positive, MPL, or Triple negative disease) or allele burden in cases of Pre-PMF with the ability of FLT-PET to differentiate between Pre-PMF and ET. Although MPNs are diseases of elderly, MPN is diagnosed in younger age groups in a considerable number of cases. Since most of the available data as well as current WHO classification criteria emphases on the "average" MPN patients who range in age between 55 and 65 years. Less consistent data are available in the groups of patients presenting below this median age, such as children and younger adults which we're planning to reveal.
Conditions
- Essential Thrombocythemia
- Primary Myelofibrosis, Fibrotic Stage
- Primary Myelofibrosis, Prefibrotic Stage
- Polycythemia Vera
Interventions
| Type | Name | Description |
|---|---|---|
| DEVICE | Diagnostic (18F-FLT PET/CT) | The tracer compound \[F-18\] FLT will be injected into the patient's veins in a small volume of normal saline solution. The PET scan data collection is started immediately and is continued for 2 hours. |
Timeline
- Start date
- 2017-06-11
- Primary completion
- 2018-10-15
- Completion
- 2018-10-16
- First posted
- 2017-04-20
- Last updated
- 2020-08-11
Locations
1 site across 1 country: Qatar
Regulatory
- FDA-regulated device study
Source: ClinicalTrials.gov record NCT03121599. Inclusion in this directory is not an endorsement.