NCT03121378

Multiple Electrode Aggregometry to Assess Platelet Function in Patients Undergoing Hip Joint Alloplasty With and Without Bone Cement

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 36 (actual)
• Sponsor: Medical University of Warsaw · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of the study is to assess blood platelet function and activation in patients undergoing both cement and non cement hip joint total alloplasty. Bone cement is used as a special biomaterial to help fix a hip prosthesis in place but is associated with bone cement implantation syndrome causing such complications as hypotension, cardiac arrhythmias. The pathophysiology of bone cement implantation syndrome is not fully known but one theory supports formation of clots in the bloodstream. This directly would activate platelets but no such study has been performed in humans. As bone reaming could potentially cause platelet activation even without bone cement, the study involves a control group of patients undergoing non cemented joint alloplasty.

Conditions

• Arthroplasty
• Methylmethacrylate Embolism
• Platelet Aggregation

Interventions

Type	Name	Description
OTHER	Blood sample 1	Blood taken before prosthesis implantation
OTHER	Blood sample 2	Blood taken after prosthesis implantation

Timeline

• Start date: 2017-04-12
• Primary completion: 2022-09-13
• Completion: 2022-09-13
• First posted: 2017-04-20
• Last updated: 2022-09-14

Locations

1 site across 1 country: Poland