NCT03097692

Does Preconditioning Affects Other Organs in Patients Undergoing Open Heart Surgery ?

Variable Types of Preconditioning,is There a Different Impact Upon Multiorgan Function After Open Heart Surgery ?

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (actual)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

An association between white blood cell count (WBC), neutrophil-lymphocyte ratio , and inflammatory process is well known . Ischemic preconditioning reduces the inflammation

Detailed description

Preliminary evidence has suggested the role of inflammation in development and prognosis of cardiovascular diseases and cancers. Most of the prognostic studies failed to account for the effects of co-morbid conditions as these might have raised the systemic inflammation. We used neutrophil lymphocyte ratio (NLR) as a measure of systemic inflammation and investigated its association with cardiac preconditioning in open heart surgery .

Conditions

• Neutrophil Lymphocyte Ratio
• Serum Createnine
• Mechanical Ventilation

Interventions

Type	Name	Description
PROCEDURE	ischemic preconditioning	ischemic preconditioning will be done after induction and before cardiopulmonary bypass by inflation the cuff of blood pressure above 200mmhg in the lower limb every 5 min for 3cycles
DRUG	Pharmacologic preconditionig	Pharmacologic preconditionig will be attained by sevoflurane anesthesia

Timeline

• Start date: 2016-05-01
• Primary completion: 2016-12-01
• Completion: 2017-03-01
• First posted: 2017-03-31
• Last updated: 2017-12-21

Locations

1 site across 1 country: Egypt