NCT03094234

8mm-TIPS Versus Endoscopic Variceal Ligation (EVL) Plus Propranolol for Prevention of Variceal Rebleeding in Patients With Child A Cirrhosis

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 72 (estimated)
• Sponsor: West China Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study was to conduct a prospective randomized trial to compare TIPS with 8mm expanded polytetrafluoroethylene(ePTFE)-covered stents and endoscopic variceal ligation plus propranolol for the prevention of recurrent esophageal variceal bleeding in patients with Child A cirrhosis

Detailed description

For the prevention of recurrent esophageal variceal bleeding, previous clinical studies and meta-analysis show that patients treated with transjugular intrahepatic portosystemic shunt (TIPS) have lower rebleeding rates compared with endoscopic therapy. However, TIPS is associated with higher rates of portosystemic encephalopathy and does not show survival benefit. TIPS with a small-diameter may achieve sufficient portal decompression and reduce the incidence of hepatic encephalopathy. The aim of this study was to conduct a prospective randomized trial to compare TIPS with 8mm ePTFE-covered stents and endoscopic variceal ligation plus propranolol for the prevention of recurrent esophageal variceal bleeding.

Conditions

• Portal Hypertension

Interventions

Type	Name	Description
DEVICE	8mm-TIPS	Patients in this group would underwent TIPS placement with 8mm-diameter ePTFE-covered stents.
PROCEDURE	endoscopic variceal ligation (EVL)	Patients in this group would underwent sequential endoscopic variceal ligation and propranolol treatment.
DRUG	Propranolol	Appropriate dose of propranolol was administered to the patients.

Timeline

• Start date: 2017-04-28
• Primary completion: 2022-03-28
• Completion: 2022-03-28
• First posted: 2017-03-29
• Last updated: 2021-11-23

Locations

1 site across 1 country: China