NCT03089476

Evaluating Skin Barrier Dysfunction in Infants at High Risk of Atopy

Hypothesis: Skin Barrier Dysfunction With Altered Expression of Skin Barrier Proteins and Lipids Predicts Early Food Sensitizations in Infants at High Risk of Atopy

• Status: Withdrawn
• Phase: N/A
• Study type: Interventional
• Enrollment: 0 (actual)
• Sponsor: National Jewish Health · Academic / Other
• Sex: All
• Age: 34 Weeks – 50 Years
• Healthy volunteers: Accepted

Summary

It is hypothesized that food allergy is preceded by atopic dermatitis (AD), due to a disruption of skin barrier which can predispose one to food sensitization through the skin. The central hypothesis is that increased transepidermal water loss (TEWL) assessment and skin tape strip analysis (STS) of lipid and filaggrin breakdown products will be predictive markers for the development of AD. Additionally, the associated changes in TEWL and STS will further improve the identification of infants at risk of early food sensitization, compared to family history alone.

Conditions

• Atopic Dermatitis
• Eczema
• Food Allergy

Interventions

Type	Name	Description
OTHER	Evaluating atopy in infants	This study does not have an intervention. There is the evaluation of the predictive value of TEWL and STS in atopic infants at risk of developing eczema and TEWL and STS in parents of infants.
OTHER	Evaluating TEWL and STS in adults	This study does not have an intervention. There is the evaluation of the predictive value of TEWL and STS in atopic infants at risk of developing eczema and TEWL and STS in parents of infants.

Timeline

• Start date: 2017-09-30
• Primary completion: 2018-07-30
• Completion: 2018-07-30
• First posted: 2017-03-24
• Last updated: 2018-06-12

Locations

1 site across 1 country: United States