NCT03083587

Frequent Activity Snacks Breaks

Frequent Activity Snacks Breaks - Interrupting Sedentary Behaviour

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Karolinska Institutet · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

There is a growing health burden in Sweden and Europe arising from the interrelated sequelae of metabolic disorders comprising impaired glucose tolerance (IGT), obesity and T2DM. Obesity and inactivity are the main drivers of IGT and T2DM and are responsible for up to 8% of health costs and 13% of deaths in Europe, with the risk of co-morbidities rising in parallel with increasing body weight. IGT and T2DM are the paradigm of inactivity-related disorders: the majority of people who have IGT or T2DM are overweight and inactive, with up to 80% being obese. A recent meta-analysis of 42 studies concluded that sedentary time was independently associated with a greater risk of T2D, all-cause mortality, cardiovascular disease incidence and mortality, and cancer incidence and mortality (breast, colon, colorectal, endometrial and epithelial ovarian cancers) (Ann Intern Med. 2015;162:123-32). A recent systematic review of trials published up to April 2014 identified 16 separate studies and concluded that there is considerable evidence of the positive effects of breaking up prolonged sitting time with light-intensity ambulatory physical activity and standing on postprandial metabolic parameters, including glucose, insulin and triglyceride levels (Med Sci Sports Exerc. 2015:47:2053-61). However, to date, all of the published experimental trials describing the beneficial effects of breaking up sitting time on metabolic risk markers have been restricted to acute exposure periods (1-5 days). We will perform a RCT intervention study, which examines the efficacy (clinically relevant responses) and practical implementation of low-impact training in sedentary obese individuals during the day.

Conditions

• Obesity
• Insulin Resistance
• Sedentary Lifestyle

Interventions

Type	Name	Description
BEHAVIORAL	Normal lifestyle	Normal lifestyle
BEHAVIORAL	Exercise	Mild exercise 3 min every half hour
PROCEDURE	muscle and fat biopsy	Biopsy under local anesthesia
DEVICE	Continuous glucose monitoring	Glucose concentrations during the study period
DEVICE	Activity monitoring (ActivePal)	Objective measurements of standing and sitting time

Timeline

• Start date: 2017-02-01
• Primary completion: 2019-07-31
• Completion: 2020-08-30
• First posted: 2017-03-20
• Last updated: 2020-09-02

Locations

1 site across 1 country: Sweden