NCT03079206

Basophile Activation Testing (BAT) in Hazelnut Allergy (Hazelnut BAT Study)

Correlation of the in Vivo Food Provocation Test With the in Vitro Basophile Activation Test in Hazelnut Allergic Patients

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 83 (actual)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 14 Years
• Healthy volunteers: Accepted

Summary

The proposed study intends to compare the outcome of food challenge in hazelnut allergic patients with the outcome of basophile activation tests using hazelnut extract and components.

Detailed description

Accurate diagnosis of food allergy depends on food challenge outcome. The proposed study intends to compare the outcome of food challenge in hazelnut allergic patients with the outcome of basophile activation tests using hazelnut extract and components to evaluate the diagnostic utility of basophile activation testing. With a view towards improved in vitro diagnostic methods, the investigators intend to evaluate the diagnostic potential of basophile activation testing in patients with hazelnut allergy confirmed by a positive provocation or supported by a convincing history of anaphylactic reaction(s) to hazelnut in the past, patients with pollinosis but no symptoms of hazelnut allergy and non-atopic control subjects.

Conditions

• Food Allergy

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Food challenge	food challenge with hazelnut
DIAGNOSTIC_TEST	skin testing	Skin testing with hazelnut extract
DIAGNOSTIC_TEST	blood sampling	blood sampling to perform basophile activation tests

Timeline

• Start date: 2017-02-22
• Primary completion: 2020-11-10
• Completion: 2020-11-10
• First posted: 2017-03-14
• Last updated: 2020-11-13

Locations

1 site across 1 country: Switzerland