NCT03068533

8% L-Arginine/Calcium Carbonate Toothpaste in Comparison to Strontium Acetate Toothpaste for Hypersensitive Dentin

The Use of 8% L-Arginine/Calcium Carbonate Containing Toothpaste in Comparison to Strontium Acetate Containing Toothpaste in Management of Hypersensitive Dentine in Chronic Periodontitis Patients : A Randomized-controlled Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 46 (actual)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Dentinal hypersensitivity \[DH\] is a common condition in daily practice, especially in patients who have abrasion, attrition, gingival recession and erosion of teeth. It can affect individuals in the age range of 20-50 years.In a recent systematic review, it was reported that no gold standard treatment modality for dentin hypersensitivity has been established Thus there is a need to evaluate new formulations in different settings and in different populations and to compare those to commonly used agents seeking better results in pain relief for our patients. Studies showed that dentifrice formulations containing 8% arginine in combination with calcium carbonate and fluoride have the ability to plug dentinal tubules, by clumping of both arginine and calcium carbonate that bind with the negatively charged dentin . Aim of the study is to clinically evaluate toothpaste containing 8% arginine, calcium carbonate, and sodium mono-fluorophosphate, in comparison to toothpaste, containing 8% strontium acetate and NaF on the relief of DH in chronic periodontitis patients.

Detailed description

1. Each eligible patient will be given a number. 2. All eligible patients will receive mechanical debridement in 1 or 2 sessions within 1 week before final evaluation. 3. The hypersensitive teeth will be isolated with cotton rolls, and stimuli will be applied to each tooth for final evaluation after scaling and debridement. 4. Air Sensitivity scale is used to assess sensitivity to air blast, while cold water test and tactile test will be held and assessed by Visual Analog Scale (VAS) , which score from 0 (no pain) to 10 (intense pain). 5. Patients will be handed a 30ml. white package written on it the previously assigned number to them and instructed to brush twice daily with the assigned toothpaste by a soft-bristled toothbrush for 8 weeks, with several returns to the clinic for re-evaluation and to take the refill of the assigned number of toothpaste. 6. Air blast sensitivity score and VAS will be evaluated again weekly and till the end of the evaluation period.

Conditions

• Dentin Hypersensitivity

Interventions

Type	Name	Description
OTHER	8% L-Arginine/calcium carbonate containing toothpaste	use of 8% L-Arginine/calcium carbonate containing toothpaste to relieve hypersensitivity
OTHER	use of strontium acetate toothpaste	use of strontium acetate toothpaste to relieve hypersensitivity

Timeline

• Start date: 2018-01-01
• Primary completion: 2018-03-03
• Completion: 2018-04-01
• First posted: 2017-03-03
• Last updated: 2018-02-14

Locations

1 site across 1 country: Egypt