NCT03067428

Effects of Fructose Restriction on Liver Steatosis

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Nonalcoholic fatty liver disease (NAFLD) is an emerging health problem as it can lead to end stage liver failure and cardiovascular complications. Diet play an important role in the development of NAFLD. Many studies have addressed the effects of added fructose on NAFLD. To date, little attention has been paid to the effects of a diet devoid of fructose. Therefore, the investigators aim to study the effects of fructose restriction on hepatic fat accumulation and vascular function using a double-blind randomized placebo-controlled design.

Conditions

• Nonalcoholic Fatty Liver Disease
• Glucose Metabolism Disorders
• Endothelial Dysfunction

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Glucose	Participants will adhere to a fructose restricted diet for a period of six weeks (\<7.5 grams/meal and/or \<10 grams/day; ad-libitum intake). In addition, the amount of fructose that will be restricted - which is based on the average individual fructose intake assessed prior to randomization - will be supplemented as glucose powder three times daily during the meal.
DIETARY_SUPPLEMENT	Fructose	Participants will adhere to a fructose restricted diet for a period of six weeks (\<7.5 grams/meal and/or \<10 grams/day; ad-libitum intake). In addition, the amount of fructose that will be restricted - which is based on the average individual fructose intake assessed prior to randomization - will be supplemented as fructose powder three times daily during the meal.

Timeline

• Start date: 2017-01-31
• Primary completion: 2019-12-20
• Completion: 2019-12-20
• First posted: 2017-03-01
• Last updated: 2020-02-21

Locations

1 site across 1 country: Netherlands