NCT03061617

Comparison of Different Ventilation Mode During One-lung Ventilation

Comparison of Pressure-controlled Ventilation With Volume-controlled Ventilation During One-lung Ventilation

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (actual)
• Sponsor: Shanghai Zhongshan Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

It is controversial as to which ventilation mode is better in one-lung ventilation(OLV), volume controlled ventilation(VCV) or pressure controlled ventilation(PCV). This study was designed to figure out if there was any difference between these two modes on oxygenation and postoperative complications under the condition of protective ventilation(PV).

Detailed description

This is a single center, single blinded prospective study on two different ventilation mode during one lung ventilation for patients under video assistant thoracoscopy(VATS) lobectomy. After institutional approval and written informed consent were obtained, 60 patients with primary lung cancer under VATS lobectomy in Zhongshan Hospital Fudan University were enrolled and randomized into two groups:VCV group(group V) or PCV group(group P). Inclusion criteria were age between 18-75 years , ASA I-II, lateral decubitus position with at least 1h OLV and preoperative FEV1\>50% predicted. Preoperative exclusion criteria were previous lobectomy , COPD , asthma, uncompensated cardiac disease or contraindications for epidural catheter. Intraoperative exclusion criteria were SpO2 under 90% after intratracheal suction, reconfirmation the position of double lumen tracheal tube(DLT) and recruitment maneuver of dependant lungs.

Conditions

• Thoracic Surgery
• One Lung Ventilation
• Ventilator-Induced Lung Injury

Interventions

Type	Name	Description
OTHER	VCV mode	set fixed 6ml/kg tide volume
OTHER	PCV mode	adjust pressure to achieve tide volume of 6ml/kg

Timeline

• Start date: 2016-07-01
• Primary completion: 2016-09-01
• Completion: 2016-12-01
• First posted: 2017-02-23
• Last updated: 2017-02-23

Locations

1 site across 1 country: China