NCT03060798

The Change of Tissue Oxygen Saturation Following Volatile Anesthesia

The Change of Tissue Oxygen Saturation Measured by Dynamic Near Infrared Spectroscopy Following Volatile Anesthesia in Healthy Population

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 60 (actual)
• Sponsor: Pusan National University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

General anesthesia can affect tissue oxygen saturation and microcirculatory reactivity. However, the differences in microcirculation caused by anesthetic methods have not been well studied. Near-infrared spectroscopy (NIRS) measures peripheral tissue oxygen saturation noninvasively and can be used in conjunction with vascular occlusion (VOT) experiments. The purpose of this study was to examine the changes in NIRS derived tissue oxygen saturation (StO2) and microcirculatory reactivity by VOT after inhalation anesthesia in healthy population. This prospective, observational study will be performed on 60 healthy patients who had undergone elective surgery under volatile general anesthesia. The investigators measure StO2 and microvascular reactivity using NIRS combined with vascular occlusion test (VOT). The parameters were performed twice per patient, before and after the induction of anesthesia. Occlusion slope and recovery slope during VOT will be compared before and after anesthesia. Moreover, the changes depend on the age will be analyzed.

Detailed description

This prospective observational study was performed on 60 patients without comorbidities who underwent elective surgery under general anesthesia. Before and after the induction of anesthesia, StO2 monitoring and VOT were performed to investigate the effect of anesthesia on microcirculation. To investigate the effect of age on microcirculation, the patients were divided into two different groups, young (\< 65 yrs) and old (\> 65 yrs) groups, and the VOT-derived parameters and hemodynamics between two groups were compared.

Conditions

• Healthy
• Aging

Interventions

Type	Name	Description
DRUG	Desflurane	general anesthesia using desflurane.
DEVICE	Near-infrared spectroscopy monitor	tissue oxygen saturation monitoring combined with vessel occlusion test

Timeline

• Start date: 2016-08-02
• Primary completion: 2017-12-31
• Completion: 2017-12-31
• First posted: 2017-02-23
• Last updated: 2020-04-14

Locations

1 site across 1 country: South Korea

Regulatory

• FDA-regulated drug study
• FDA-regulated device study