NCT03047291

Effect of Probiotic Lactobacillus Reuteri in the Treatment of Mucositis and Periimplantitis

Clinical and Microbiological Evaluation of the Effect of Probiotic Lactobacillus Reuteri Prodentis in the Treatment of Mucositis and Periimplantitis

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 44 (actual)
• Sponsor: Universitat Internacional de Catalunya · Academic / Other
• Sex: All
• Age: 18 Years – 99 Years
• Healthy volunteers: Accepted

Summary

Evaluate clinically and microbiologically the effect of the oral probiotic Lactobacillus reuteri Prodentis (PerioBalance®, Sunstar, Switzerland) on implants with mucositis or periimplantitis, as a coadjuvant treatment of mechanical therapy.

Detailed description

A total of 44 patients, 22 with mucositis and 22 with periimplantitis, were randomly assigned to either the control or the test group, so that 11 patients received placebo and 11 probiotic treatment. After the baseline clinical, radiological and microbiological examination, and once the study group was randomly assigned (probiotic or placebo), supragingival prophylaxis was performed in the mucositis group and subgingival mechanical therapy in the periimplantitis group. Then they get a container with 30 probiotic or placebo tablets and instructions on how and when to take them. At 30 and 90 days after beginning the treatment, a clinical, radiological and microbiological examination was performed.

Conditions

• Mucositis
• Peri-implantitis

Interventions

Type	Name	Description
DRUG	Probiotic	30 probiotic tablets were given after the mechanical debridement of implants with mucositis and periimplantitis.
DEVICE	Placebo Oral Tablet	30 placebo tablets were given after the mechanical debridement of implants with mucositis and periimplantitis.

Timeline

• Start date: 2014-01-01
• Primary completion: 2017-03-01
• Completion: 2017-09-01
• First posted: 2017-02-08
• Last updated: 2020-03-30