NCT03037372

Statin Adjunct Therapy Among ART-treated Adults in Sub-Saharan Africa: Atorvastatin and Rosuvastatin Equivalence Trial

Statin Adjunct Therapy Among HAART-treated Adults in Sub-Saharan Africa: Equivalence of Atorvastatin and Rosuvastatin

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 320 (estimated)
• Sponsor: Makerere University · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This study will determine whether 36 months of daily atorvastatin or rosuvastatin have equivalent effects in reduction of immune activation, inflammation and immune aging, when given as adjunct therapy among patients receiving antiretroviral therapy in an African cohort

Detailed description

This is a randomized, open-label trial

Conditions

• HIV Infection

Interventions

Type	Name	Description
DRUG	ART, Atorvastatin	ART, Atorvastatin
DRUG	ART, Rosuvastatin	ART, Rosuvastatin
DRUG	ART, No statin	ART, No statin
DRUG	Healthy-HIV-negative	Age-matched, Healthy HIV-negative

Timeline

• Start date: 2017-06-01
• Primary completion: 2022-06-30
• Completion: 2022-12-31
• First posted: 2017-01-31
• Last updated: 2017-01-31