NCT03028428

Intra-articular Injection of MSCs in Treatment of Knee OA

Clinical Research on Intra-articular Injection of Human Autologous MSCs in Treatment of Knee OA

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 1 (estimated)
• Sponsor: Affiliated Hospital of Jiangsu University · Academic / Other
• Sex: All
• Age: 40 Years – 75 Years
• Healthy volunteers: Not accepted

Summary

In this study, researchers want to determine the safety of MSCs that a patient can tolerate without causing side effects. Moreover researchers will also be looking at the function of the knee over time, which may give them some insight on the usefulness of MSCs as a treatment option.

Detailed description

Osteoarthritis (OA) is one of the most common forms of arthritis. It is a lasting condition in which the material that cushions the joints, called cartilage, breaks down. This causes the bones to rub against each other, causing inflammation, stiffness, pain and loss of joint movement. Currently, there are few effective treatments available for patients suffering from OA. Mesenchymal stem cells (MSCs) are cells that have the ability to self-regenerate, which means they have the ability to make copies of themselves and to turn into other kinds of cells (e.g. cartilage cells). Stem cell science shows much promise for the future treatment of osteoarthritis, but much of the research is still in the early stages. In this study, researchers want to determine the safety of MSCs that a patient can tolerate without causing side effects. Moreover researchers will also be looking at the function of the knee over time, which may give them some insight on the usefulness of MSCs as a treatment option.

Conditions

• Osteoarthritis
• Stem Cells
• MSC

Interventions

Type	Name	Description
BIOLOGICAL	Placenta Derived Mesenchymal Stem Cell	1ml 1\*10\^7 Placenta Derived Mesenchymal Stem Cell administered into the knee joint once
DRUG	Sodium Hyaluronate	Sodium hyaluronate administered into the knee joint once

Timeline

• Start date: 2016-12-01
• Primary completion: 2018-12-01
• Completion: 2019-12-01
• First posted: 2017-01-23
• Last updated: 2018-01-30