NCT03022838

The Effects of Caffeine Withdrawal on Migraine

The Effects of Caffeine Withdrawal on Migraine - a Randomized, Double-blind, Crossover Study

• Status: Terminated
• Phase: Phase 2 / Phase 3
• Study type: Interventional
• Enrollment: 10 (actual)
• Sponsor: Nordlandssykehuset HF · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Sporadic and chronic dietary consumption of caffeine has substantial biological effects on the nervous system. The effects on migraine are at large not known. In this study we want to assess the effects of caffeine withdrawal on migraine.

Detailed description

The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. The current opinion is that caffeine both can cure and trigger headaches. Caffeine is a component of many combination drugs marketed for the relief of headaches, but on the other hand it is strongly incriminated as a risk factor for developing chronic headache. Withdrawal may cause symptom constellations similar to the migraine syndrome. Further, caffeine consumption may affect sleep and alertness, possibly influencing the risk of migraine attacks. .

Conditions

• Migraine
• Caffeine Withdrawal

Interventions

Type	Name	Description
DRUG	Caffeine	From the point of enrollment, patients will substitute their daily dietary caffeine with either placebo- or capsulated caffeine tablets (Recip®, 100mg).

Timeline

• Start date: 2017-02-28
• Primary completion: 2019-07-22
• Completion: 2019-07-22
• First posted: 2017-01-18
• Last updated: 2019-07-23

Locations

3 sites across 1 country: Norway