NCT03012997

Effects of Hyperoxia on Open Heart Surgery

Effects of Hyperoxia on Oxidative Stress in Patients Undergoing Open Heart Surgery

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Istanbul University · Academic / Other
• Sex: All
• Age: 20 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Patients undergoing Open Cardiac Surgery will be randomized into two groups. Group I will be ventilated with 40% Fio2 during induction, surgery and in Postoperative care unit. Group II will be ventilated with 100% Fio2 during induction and with 60-70% ( determined according to the arterial blood gas sample results) during surgery and in Postoperative care unit. Hemodynamic parameters ( systolic arterial pressure, diastolic arterial pressure, heart rate ), Arterial blood gas samples ( PaO2, PaCO2, pH, Oxygen saturation, Lactate), and pre and post cardiopulmonary bypass Superoxide dismutase and malonyl aldehyde levels.

Conditions

• Heart Valve Disease
• Coronary (Artery) Disease

Interventions

Type	Name	Description
OTHER	Fraction of inspired oxygen 40%
OTHER	Fraction of inspired oxygen 100%

Timeline

• Start date: 2016-12-01
• Primary completion: 2017-04-01
• Completion: 2017-04-01
• First posted: 2017-01-06
• Last updated: 2017-01-06

Locations

2 sites across 1 country: Turkey (Türkiye)