NCT03000764

RNA and Heat Shock Protein Biomarkers in Radiation-induced Fibrosis in Breast Cancer

Study of RNA and Heat Shock Protein (HSP) Derived Biomarkers in Radiation-induced Fibrosis in Patients Treated for Breast Cancer.

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Institut de Cancérologie de Lorraine · Academic / Other
• Sex: Female
• Age: 18 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to seeking a molecular signature of pathological radiation induced fibrosis based on the response of skin fibroblasts after irradiation, comparing two groups of patients distinguished by their individual radiosensitivity. The signature will integrate recent insights in terms of alternative splicing of mRNAs and level of expression of non-coding RNAs, particularly long non-coding RNAs, snRNAs, snoRNAs and microRNAs. In each group each expression patterns of candidate HSP proteins potentially predictive of pathological radiation induced fibrosis (HSP27, HSP70, αβ crystalline) in the serum and on cell culture will be characterized.

Conditions

• Breast Carcinoma
• Fibrosis

Interventions

Type	Name	Description
OTHER	skin biopsies	Biopsies (12 G) will be performed : * in non-irradiated breast skin * in irradiated breast skin
OTHER	blood samples	blood samples are collected: * 10 ml in EDTA tube * 2,5 ml in PAXgene Blood RNA tube * 4 ml in EDTA tube

Timeline

• Start date: 2017-05-10
• Primary completion: 2018-04-18
• Completion: 2018-04-25
• First posted: 2016-12-22
• Last updated: 2018-08-08

Locations

1 site across 1 country: France