NCT03000582

Assessment of Different Forms of Creatine

Pharmacokinetic Assessment of Acute Ingestion of Different Forms of Creatine

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 13 (actual)
• Sponsor: Texas A&M University · Academic / Other
• Sex: —
• Age: —
• Healthy volunteers: Accepted

Summary

The purpose of this study is to examine the pharmacokinetics of creatine nitrate supplementation.

Detailed description

Creatine nitrate contains several nutrients that may increase anaerobic exercise performance. Theoretically, dietary supplementation of creatine nitrate during resistance training can improve the quality of training leading to greater changes in strength, power and fat free mass. Endothelial function measured by flow-mediated dilation (FMD), a non-invasive vascular health parameter that can be measured via ultrasonography, is a predictor of cardiovascular disease risk which precedes traditional risk markers. Diet, physical activity and pharmaceutical interventions can all impact vascular function and health. The purpose of this study is to determine the acute vascular response of creatine nitrate supplementation on FMD by analyzing the pharmacokinetics of creatine nitrate supplementation.

Conditions

• Dietary Modification

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Creatine monohydrate	Creatine monohydrate (5.0 g creatine monohydrate, 1.5 g dextrose)
DIETARY_SUPPLEMENT	Creatine nitrate-1	Creatine nitrate-1 (1.0 g creatine monohydrate, 0.5 g nitrate, 5.0 g dextrose)
DIETARY_SUPPLEMENT	Creatine nitrate-2	Creatine nitrate-2 (2.0 g creatine monohydrate, 1.0 g nitrate, 3.5 g dextrose)
DIETARY_SUPPLEMENT	Placebo	Placebo (6.5 g dextrose)

Timeline

• Start date: 2014-06-01
• Primary completion: 2014-09-01
• Completion: 2014-09-01
• First posted: 2016-12-22
• Last updated: 2016-12-22