NCT02997007

Neural Correlates of Repeated tDCS

Investigating the Neural Correlates of Repeated tDCS in MCI and Healthy Ageing With fMRI

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 60 Years – 85 Years
• Healthy volunteers: Accepted

Summary

Healthy ageing and pathological ageing in the context of a neurodegenerative disease are both associated with changes in brain network integrity. Episodic memory is especially affected in Alzheimer's disease, but is also decreased in healthy ageing. Consequently, the memory-relevant brain networks are especially altered. Transcranial direct current stimulation (tDCS) has previously been implemented in different clinical- and non-clinical settings and has shown to beneficially influence network connectivity. The neural correlates of single-session tDCS have been investigated, however, the neural effects of repeated tDCS remain unknown. Furthermore, knowledge about the (long-term) neural mechanisms of repeated tDCS can give valuable insights and possibly pave the ground for exploring tDCS as a treatment option in future studies.

Conditions

• Mild Cognitive Impairment

Interventions

Type	Name	Description
DEVICE	active tDCS	Participants will receive active tDCS over the angular gyrus on five consecutive days
DEVICE	sham tDCS	Participants will receive sham tDCS over the angular gyrus on five consecutive days

Timeline

• Start date: 2017-05-02
• Primary completion: 2018-12-01
• Completion: 2018-12-01
• First posted: 2016-12-19
• Last updated: 2018-03-26

Locations

1 site across 1 country: Netherlands