NCT02987491

Exercise and Insulin Signaling in Human Skeletal Muscle

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (actual)
• Sponsor: Oregon State University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Accepted

Summary

Obesity is associated with a decrease in skeletal muscle insulin sensitivity. Aerobic exercise can increase insulin sensitivity in the few hours following exercise, however the cellular mechanisms are not completely understood. The current project is to investigate mechanisms of exercise improvements to skeletal muscle insulin sensitivity.

Detailed description

Study Overview: We are investigating the mechanisms by which exercise improves the response of skeletal muscle to insulin in lean and obese adults. Participants will complete 4 study visits consisting of: 1) screening visit, 2) maximal exercise test visit, and then a randomized order of 3) a resting metabolic study visit, and 4) an exercise metabolic study visit. Metabolic study visits for resting and exercise conditions will be identical, other than remaining sedentary or performing exercise. Skeletal muscle biopsy samples will be collected during resting, immediately post-exercise and during insulin stimulated conditions.

Conditions

• Insulin Sensitivity
• Obesity
• Sedentary Lifestyle

Interventions

Type	Name	Description
BEHAVIORAL	Exercise	Participants will perform 2 metabolic study days of either resting or acute bout of cycling exercise in a randomized cross-over design.

Timeline

• Start date: 2016-11-01
• Primary completion: 2018-06-28
• Completion: 2018-06-28
• First posted: 2016-12-09
• Last updated: 2019-08-28

Locations

1 site across 1 country: United States