NCT02976883

[18F]HX4 PET/CT Imaging for Detection of Hypoxia

A Phase II, Single Centre Exploratory Study of [18F]HX4 PET/CT Imaging to Detect Hypoxia in Patients With Head and Neck and Lung Cancer, Receiving Radiotherapy With Curative Intent

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 8 (actual)
• Sponsor: Nottingham University Hospitals NHS Trust · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to investigate the radiotracer \[18F\]HX4 for non-invasive detection of hypoxia in patients with head and neck, or lung cancer. Each participant will undergo a diagnostic \[18F\]HX4 PET/CT scan before beginning radiotherapy treatment. Patient follow up data will be collected from routine appointments, and analysed with the hypoxia scan results to assess whether \[18F\]HX4 PET/CT scanning can predict patient outcome from radiotherapy treatment.

Conditions

• Head and Neck Cancer
• Lung Cancer

Interventions

Type	Name	Description
OTHER	[18F]HX4 diagnostic PET/CT scan	Single intravenous injection of \[18F\]HX4 and PET/CT scan

Timeline

• Start date: 2015-03-31
• Primary completion: 2017-07-25
• Completion: 2017-07-25
• First posted: 2016-11-29
• Last updated: 2019-01-11

Locations

1 site across 1 country: United Kingdom