NCT02952521

Ovarian Tumor Biopsies to Study Response to Treatments

Paired Biopsies to Develop a Cellular Signature

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 5 (actual)
• Sponsor: University Health Network, Toronto · Academic / Other
• Sex: Female
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This is a research study to look at differences in tumor tissue from ovarian cancer patients that may help to determine response and resistance to treatments.

Detailed description

Ovarian cancer participants will be asked to have two tumor biopsies during the research study. The first biopsy will be done prior to receiving the participants' assigned treatments as a part of their cancer care and the second biopsy will be done about 3-7 days after starting treatment. Participants who will undergo neoadjuvant treatment and then surgery, will also have their tumor tissue collected during surgery. Participants whose disease worsens while on treatment will also be asked to have an additional, optional tumor biopsy. The tumor tissue samples will be studied to look at certain proteins and enzymes, including enzymes called kinomes, that may be important in determining response and resistance to the treatment that participants will receive as a part of their cancer care.

Conditions

• Epithelial Ovarian Cancer

Interventions

Type	Name	Description
PROCEDURE	Blood Draw	CA125 and ctDNA
PROCEDURE	Tumor Tissue Biopsy	Only collected at time of surgery if patient undergoes surgical debulking

Timeline

• Start date: 2017-01-25
• Primary completion: 2021-10-28
• Completion: 2021-10-28
• First posted: 2016-11-02
• Last updated: 2022-05-10

Locations

1 site across 1 country: Canada