NCT02952170

Impact of Weight Loss Surgery in Adolescents With NAFLD

The Impact of Weight Loss Surgery in Adolescents on Fatty Liver Disease

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 11 (actual)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 15 Years – 22 Years
• Healthy volunteers: Not accepted

Summary

This study will assess the impact of weight loss surgery (WLS) on non-alcoholic fatty liver disease (NAFLD) in adolescents as well as the interaction between NAFLD and cardiometabolic risk.

Detailed description

While the impact of WLS has been studied in adults, little is known about NAFLD in adolescents undergoing WLS. At present, only a small number of adolescents undergo WLS each year and thus this area has not been well studied. However, as the prevalence of severe obesity continues to rise the investigators anticipate that so will WLS in adolescents. This study will establish the impact of WLS on NAFLD in adolescents. Currently, it is assumed that adolescents with NAFLD diagnosed at the time of WLS have universal resolution of their disease with appropriate weight loss, and no further evaluation is conducted. Our group has shown that up to 40% of adolescents who undergo WLS have persistently abnormal aminotransferase levels, suggesting that many may have persistent NASH and are at risk of progressive liver disease. The study will elucidate the history of NAFLD following WLS. Such data have not been previously published and will represent a significant contribution to this field.

Conditions

• NAFLD
• Obesity, Adolescent

Interventions

Type	Name	Description
OTHER	MRI	MRI to assess hepatic steatosis

Timeline

• Start date: 2014-09-15
• Primary completion: 2021-12-30
• Completion: 2022-04-30
• First posted: 2016-11-02
• Last updated: 2023-03-15

Locations

1 site across 1 country: United States