Trials / Completed
CompletedNCT02949934
Effects of Cortical Dopamine Regulation on Drinking, Craving, and Cognitive Control
- Status
- Completed
- Phase
- Phase 2
- Study type
- Interventional
- Enrollment
- 90 (actual)
- Sponsor
- Medical University of South Carolina · Academic / Other
- Sex
- All
- Age
- 21 Years – 40 Years
- Healthy volunteers
- Not accepted
Summary
The purpose of this study is to determine whether the catechol-O-methyltransferase (COMT) inhibitor tolcapone, relative to placebo, reduces alcohol drinking and alcohol cue-elicited brain activation and increases brain activation associated with cognitive control as a function of a participant's genotype at a polymorphism in the COMT gene.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DRUG | Tolcapone | |
| DRUG | Placebo |
Timeline
- Start date
- 2016-05-01
- Primary completion
- 2021-04-13
- Completion
- 2021-04-13
- First posted
- 2016-10-31
- Last updated
- 2023-06-09
- Results posted
- 2022-04-15
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT02949934. Inclusion in this directory is not an endorsement.