NCT02939339

Theta Burst TMS as a Tool to Change Smoking Behavior

• Status: Completed
• Phase: EARLY_Phase 1
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: Medical University of South Carolina · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in decreasing craving in individuals who habitually smoke cigarettes. The study consists of six total visits to MUSC; one for the consent process, two that will include MRI scans, and five that will include TMS administration. Compensation will be provided for each visit.

Detailed description

Prior and recent evidence suggests a role of medial prefrontal cortex (mPFC) in cigarette smoking. The present study will examine whether a five-day regimen of theta-burst transcranial magnetic stimulation (TMS) reduces cigarette smoking outside of the lab (examined through self-report and physiological measures) and motivation to smoke inside the lab (examined through behavioral tasks and functional MRI).

Conditions

• Smoking
• Addiction

Interventions

Type	Name	Description
DEVICE	continuous theta burst stimulation (real)	a form of transcranial magnetic stimulation that noninvasively induces a depression in brain reactivity
DEVICE	continuous theta burst stimulation (sham)	a sham version of a form of transcranial magnetic stimulation that noninvasively induces a depression in brain reactivity

Timeline

• Start date: 2015-10-01
• Primary completion: 2017-08-01
• Completion: 2017-08-01
• First posted: 2016-10-20
• Last updated: 2018-07-23

Locations

1 site across 1 country: United States