NCT02931383

Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis; Weight Maintenance

Ultrasound of the Knee in Obese Patients With Knee Osteoarthritis Following Liraglutide Treatment, Investigating the Impact on Inflammation

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Henrik Gudbergsen · Academic / Other
• Sex: All
• Age: 18 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (OA) (NCT02905864). In the parent trial, patients will be subjected to an 8-week diet intervention phase including a low-calorie diet and dietetic counseling, after which patients will be randomised to receive either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic guidance on re-introducing regular foods and a focus on continued motivation to engage in a healthy lifestyle. This substudy aims to investigate the impact of, and subsequent change of, joint inflammation and clinical symptoms, in obese patients with knee osteoarthritis following a randomisation to Liraglutide 3 mg or Liraglutide 3 mg placebo treatment between weeks 0-52.

Conditions

• Osteoarthritis
• Obesity

Interventions

Type	Name	Description
DRUG	Liraglutide 3 mg (Saxenda)
DRUG	Liraglutide 3 mg placebo

Timeline

• Start date: 2016-11-01
• Primary completion: 2019-02-01
• Completion: 2019-03-01
• First posted: 2016-10-13
• Last updated: 2019-03-25

Locations

1 site across 1 country: Denmark