NCT02929914

Effect of aPDT on Deep Caries in Permanent Tooth

Effect of Antimicrobial Photodynamic Therapy on Deep Caries in Permanent Tooth: A Pilot Randomized Controlled Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Fujian Medical University · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

The aim of this study is to assess the clinical effect of aPDT on deep caries in permanent teeth. Half of the deep caries will receive aPDT disinfect in restorative treatment procedure, while the other half will receive sodium 0.9% saline in restorative treatment procedure.

Detailed description

The aim of the proposed study is to assess the clinical effect of antimicrobial photodynamic therapy (aPDT) using LED on dentin with deep caries in permanent teeth. Permanent teeth with deep carious lesions on the occlusal surface indicated for restorative treatment will be randomly allocated to two groups: Group 1 -Control after incomplete caries removal, washed with sodium 0.9% saline; Group 2 - PDT + CH after incomplete caries removal, disinfect the residual dentin with PDT(LED + O-Toluidine Blue). Dentin samples will be collected before and after disinfect for microbiological analysis. Then the teeth will be capped with CH and restored using resin with clinical and radiographic follow up at 6, 12 and 24 months.

Conditions

• Dental Caries

Interventions

Type	Name	Description
PROCEDURE	Local anesthesia and rubber dam isolation	Local anesthesia was performed. Tooth was isolated using a rubber dam isolation in order to collect the dentin samples.
PROCEDURE	Incomplete caries removal and microbiological samples collection	Partial carious tissue was removed with conventional dentinal curette and collection of dentin with a spoon (1#) was performed.
PROCEDURE	Dentin washed with sodium 0.9% saline	The remaining dentin was dipped in sodium 0.9% saline for 2min.
PROCEDURE	Antimicrobial Photodynamic Therapy	The remaining dentin was disinfected with aPDT for 2 min.
PROCEDURE	Microbiological samples collection and Indirect pulp treatment	A new dentin collection was performed after this treatment at another site of the cavity. Then teeth were conventionally restored using the following materials: calcium hydroxide lining material and resin (Z350,3M).

Timeline

• Start date: 2016-06-01
• Primary completion: 2024-12-01
• Completion: 2025-12-01
• First posted: 2016-10-11
• Last updated: 2023-09-21

Locations

1 site across 1 country: China