NCT02928614

Biomarkers in Obese Patients With Knee Osteoarthritis; Weight Maintenance

Biomarkers in Obese Patients With Knee Osteoarthritis Following Long-term Weight Maintenance

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 150 (estimated)
• Sponsor: Henrik Gudbergsen · Academic / Other
• Sex: All
• Age: 18 Years – 74 Years
• Healthy volunteers: Not accepted

Summary

This is a substudy to a randomized trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864). In the parent trial, patients will be subjected to an 8-week diet intervention phase including a low-calorie diet and dietetic counseling, after which they will be randomized to receive either liraglutide 3 mg or liraglutide 3 mg placebo as an add-on to dietetic guidance on re-introducing regular foods and a focus on continued motivation to engage in a healthy lifestyle. This substudy aims to investigate the impact of, and subsequent change of biomarkers in obese patients with knee osteoarthritis following a randomization to Liraglutide 3 mg or Liraglutide 3 mg placebo treatment between weeks 0-52.

Conditions

• Osteoarthritis
• Obesity

Interventions

Type	Name	Description
DRUG	Liraglutide 3 mg (Saxenda)
DRUG	Liraglutide 3 mg placebo

Timeline

• Start date: 2016-11-01
• Primary completion: 2019-02-01
• Completion: 2019-03-01
• First posted: 2016-10-10
• Last updated: 2019-03-25

Locations

1 site across 1 country: Denmark