NCT02927522

Donepezil Attenuate Postoperative Cognitive Dysfunction

Donepezil Attenuate Postoperative Cognitive Dysfunction in Aged Patients- A Multi-center, Case Control, Randomized Clinical Trail

• Status: Unknown
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 550 (estimated)
• Sponsor: RenJi Hospital · Academic / Other
• Sex: All
• Age: 60 Years
• Healthy volunteers: Accepted

Summary

Postoperative cognitive dysfunction (POCD) occurs mainly in aged patients. POCD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to our previous study, the central cholinergic system impaired by the anesthesia and surgery play a very important role in the POCD and donepezil an acetylcholinesterase inhibitor can prevent the POCD after isoflurane anesthesia in aged mice. Donepezil is a commercial medicine used for the Alzheimer Disease, which is tolerable and has minimal adverse events. In present study a multi-center randomized case control study was conducted and we hypothesized that donepezil attenuate the POCD.

Conditions

• Osteoarthritis
• Femoral Head Necrosis
• Rheumatoid Arthritis

Interventions

Type	Name	Description
DRUG	Donepezil	Donepezil a cholinesterase inhibitor, 5mg(1 pill)/ day for 7 days Po, was administrated from the day before surgery.
DRUG	Placebo	Placebo, 1 pill/ day for 7 days Po, was administrated from the day before surgery.

Timeline

• Start date: 2018-09-01
• Primary completion: 2021-12-01
• Completion: 2021-12-01
• First posted: 2016-10-07
• Last updated: 2020-01-30

Locations

1 site across 1 country: China