NCT02922478

Role of Comorbidities in Chronic Heart Failure Study

Role of Comorbidities in Chronic Heart Failure (RoC-HF) Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 205 (actual)
• Sponsor: Medical University of Graz · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to create a database of patients with stable and chronic heart failure with comprehensive assessment of bone, skeletal and vascular status. RoC-HF will facilitate cross-sectional and, eventually, longitudinal mechanistic epidemiological analyses to disentangle the role of the bone- vascular axis in chronic heart failure. Blood and urine samples will be stored to facilitate future biomarker analyses.

Conditions

• Heart Failure
• Comorbidity
• Osteoporosis
• Pulse Wave Analysis
• Blood Pressure Monitoring, Ambulatory
• Osteoporotic Fractures

Interventions

Type	Name	Description
RADIATION	X-ray of the spine	Every participant will undergo X-ray of the spine so that vertebral fractures can be quantified using the Genant score.
PROCEDURE	Ambulatory blood pressure monitoring (ABPM)	ABPM will be performed using the brachial, oscillometric, automated self-measurement mobil-O-Graph device (I.E.M. GmbH, Stolberg, Germany) with integrated ARCSolver®-Software (Austrian Institute of Technology Wien).
RADIATION	Dual X-ray absorptiometry	Individual bone mineral density and T-Score will be determined by X-ray absorptiometry.
PROCEDURE	Non-invasive procedures	Other non-invasive study procedures include structured patient interview, sampling of blood, buffy coat and spot urine (including biobanking), electrocardiogram, pulse wave velocity and analysis, transthoracic echocardiography, 4-meter gait speed test, hand grip test, questionnaires

Timeline

• Start date: 2016-09-01
• Primary completion: 2018-12-20
• Completion: 2018-12-20
• First posted: 2016-10-04
• Last updated: 2019-06-24

Locations

1 site across 1 country: Austria