NCT02918981

Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 50 (actual)
• Sponsor: University of Illinois at Urbana-Champaign · Academic / Other
• Sex: Female
• Age: 20 Years – 79 Years
• Healthy volunteers: Accepted

Summary

Using stable isotope methodology, investigators will determine the postabsorptive and postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: \<30 kg/m2) immediately after an acute bout of resistance exercise. Participants will be divided in to 5 groups of twelve women (n=12). Each group will receive a different protein beverage or placebo to consume following the resistance exercise training. Group 1 will consume a beverage consisting of whey protein; group 2 will consume whey protein supplemented with additional leucine; group 3 will consume whey protein supplemented with additional leucine and hydrolyzed whey peptides; group 4 will consume whey protein supplemented with additional leucine and citrulline; group 5 will just consume water. During the testing, blood and muscle samples will be collected.

Conditions

• Aging

Interventions

Type	Name	Description
BEHAVIORAL	Resistance Exercise	Participants will perform unilateral leg extension exercise immediately prior to ingestion of the experimental beverage
DIETARY_SUPPLEMENT	14 g Whey protein
DIETARY_SUPPLEMENT	6.6 g Whey protein + 1.25 g leucine
DIETARY_SUPPLEMENT	4 g Whey protein + 1.25 g leucine + 2.6 g Whey peptides
DIETARY_SUPPLEMENT	6.6 g Whey protein + 1.25 g leucine + 0.8 g Citrulline
OTHER	Water control

Timeline

• Start date: 2016-10-01
• Primary completion: 2019-03-06
• Completion: 2019-03-06
• First posted: 2016-09-29
• Last updated: 2020-11-03

Locations

1 site across 1 country: United States