NCT02913729

Pre- Versus Postoperative Accelerated Partial Breast Irradiation

Pre- Versus Postoperative Accelerated Partial Breast Irradiation in Early Stage Breast Cancer Patients

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: The Netherlands Cancer Institute · Academic / Other
• Sex: Female
• Age: 51 Years
• Healthy volunteers: Not accepted

Summary

Most of the local recurrences (LR) found after breast-conserving therapy are within or close to the tumor bed. This pattern of recurrence was confirmed by studies of breast conserving surgery without adjuvant irradiation and by the update of the NSABP B-06 trial. In the EORTC boost trial, however, 29% of all LR were found outside the area of the original tumor. Still, a recent review of Breast Conserving Therapy (BCT) trials showed that the site of local recurrences after BCT was mostly in the tumor bed, with less than 10% of LR elsewhere in the breast. This led to the concept of partial breast irradiation. With accelerated partial breast irradiation (APBI), a limited volume of breast tissue is irradiated, allowing for a higher dose per fraction compared to whole breast irradiation (WBI), which is favorable considering the low alpha/beta ratio, and thus higher sensitivity to high dose per fraction.

Detailed description

Patients will undergo a partial accelerated breast irradiation pre-or postoperative of 5 x 5.2 Gy

Conditions

• Breast Cancer
• Cancer of the Breast
• Neoplasms, Breast

Interventions

Type	Name	Description
RADIATION	partial breast irradiation	irradiation

Timeline

• Start date: 2016-11-10
• Primary completion: 2022-02-28
• Completion: 2022-02-28
• First posted: 2016-09-26
• Last updated: 2022-09-29

Locations

6 sites across 4 countries: France, Netherlands, Portugal, Spain