NCT02901990

Observational Study to Assess Protection to Mumps in Children Received One-dose Mumps-containing Vaccine

Observational Cohort Study to Evaluate Immunogenicity, Protection, and Persistence of Antibody to Mumps in 3-7 Years' Children Received One-dose Mumps-containing Vaccine

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 7,901 (actual)
• Sponsor: Jiangsu Province Centers for Disease Control and Prevention · Network
• Sex: All
• Age: 3 Years – 7 Years
• Healthy volunteers: Accepted

Summary

This study was aimed to conduct a 3-year perspective study to observe the immunological effect of one-dose mumps-containing vaccine, monitor the incidence of mumps in vaccinated population aged 3-7 years，and provide basis for adjusting MMR immunization strategy in Jiangsu province, China.

Detailed description

in 3-7 years old children with high risk of mumps, epidemiological investigation of the serum IgG antibody level were conducted, and then a prospective observational cohort was established in the population with a history of mumps vaccination, and the incidence of mumps in each antibody level group will be observed, the relationship between different antibody levels and the incidence after mumps vaccinated were analyzed, to explore attenuation of mumps IgG antibody levels in the body,S79 vaccine strain against F genotype mumps' antigenic cross-reactivity and the protective effect of antibodies.

Conditions

• Parotid Gland Infection
• Fever

Timeline

• Start date: 2015-10-01
• Primary completion: 2017-02-02
• Completion: 2017-02-02
• First posted: 2016-09-15
• Last updated: 2017-06-06

Locations

6 sites across 1 country: China