NCT02891343

Effect of Hypoxia on Cognitive Assessment and Cerebral Activity in Healthy Volunteers

Effect of Hypoxia on Cognitive Assessment and Cerebral Activity in Healthy Volunteers WP1 P002 PHARMACOG

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University Hospital, Lille · Academic / Other
• Sex: Male
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

The early assessment of new symptomatic drugs for Alzheimer disease remains difficult because of the lack of predictive end-point. The use of a battery including different parameters could improve this early development. In healthy volunteers, to test the reverse effect of symptomatic drugs, it is necessary to induce transient and reversible cognitive impairment and cerebral activity changes by a challenge test. In this context, a transient hypoxia could be relevant.

Conditions

• Alteration of Cognitive Function
• Hypoxia

Interventions

Type	Name	Description
OTHER	2-hour period of hypoxia	During this period, the FiO2 will be set on 21% (normoxia condition). A filter will be put between the mask and the tubes connecting it to the machine generating hypoxia (equipment reference = Altitrainer NP190). On that filter a gas analyser will monitor the FiO2 and a capnography monitor (Capnostream 20, ORIDION) will also be installed.

Timeline

• Start date: 2015-11-01
• Primary completion: 2021-05-01
• Completion: 2021-05-01
• First posted: 2016-09-07
• Last updated: 2020-08-26

Locations

2 sites across 1 country: France